Melatonina Zinco-Selenio Pierpaoli

Melatonin Zinc-Selenium


This formulation is the result of fundamental scientific observations, which surfaced and came to a head during the 40 years of research and clinical trials on Melatonin, the Pineal Gland and aging mechanisms conducted by Prof. Walter Pierpaoli and his collaborators.

Pierpaoli’s Melatonin Zinc-Selenium was developed with the intent of achieving a peak in the release of Melatonin during the night, which helps re-establish the nocturnal peak of melatonin and was formulated to satisfy the physiological needs of the body functions.



Dietary supplement with melatonin, zinc and selenium.

Formula developed on the basis of clinical trials.


Melatonin contributes to reducing the time needed to fall asleep; the beneficial effect is obtained by taking 1 mg of Melatonin just before going to bed.


Melatonin contributes to reducing the effects of jet lag.


Zinc contributes to protecting cells from oxidative stress and the normal function of the immune system. Selenium contributes to protecting the cells from oxidative stress.


Average values per daily dose (1 tablet):
Melatonin 1 mg, Zinc 8,7 mg (NRV 87%), Selenium 50 mcg (NRV 90%)


Pack of 60 tablets


Melatonin, Zinc gluconate, Seleniomethionine and Mannitol


Instruction for use

We recommend taking one tablet of Pierpaoli’s Melatonin Zinc-Selenium in the evening half an hour before going to sleep, and in any case preferably between 10 p.m. and midnight.


Do not exceed the recommended daily dose. Supplements are not intended as a substitute for a varied, balanced diet and healthy lifestyle. Keep out of reach of children under three years of age, do not take while pregnant, keep at a temperature below 25° C and protect from light. Excessive use may cause laxative effects due to the mannitol presence. 



Melatonin is a simple natural molecule secreted, in addition to the pineal gland, also in numerous other organs and tissues, it has also been found in many plants, including many for food use. 


Melatonin plays an important role in the regulation of circadian cycles and sleep-wake rhythms, it is a powerful antioxidant, has chronobiological and, consequently, also physiological functions.


Melatonin has demonstrated its effectiveness, especially in contributing to restore the natural biological rhythms of the body; Melatonin supplementation can be useful in certain circadian rhythm disorders and sleep disorders.

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Safety considerations for Pierpaoli’s Melatonin Zinc-Selenium


In general

The use of Melatonin at the recommended doses is safe. Melatonin is generally well tolerated and has no side effects. No harmful or dangerous side effects have been identified in the 20 years during which tens of millions of people have taken Melatonin. Numerous scientific publications and studies confirm the safety and beneficial effects of Melatonin.

The medical- scientific literature demonstrates the good tolerance of melatonin, even at high doses, with only mild adverse effects similar in type and frequency to placebo.

Melatonin is practically free of contraindications and clinically relevant undesirable effects when taken according to instructions.

Pierpaoli’s Melatonin Zinc-Selenium does not create addiction or dependency. Stopping the administration of exogenous Melatonin, the pineal gland resumes synthesizing the endogenous molecule in physiological quantities.


We recommend that you always consult your doctor if:

  • You are being treated with medications, to make sure there are not contraindications or possible interactions;
  • The use is for children or women during breastfeeding;
  • You are taking other supplements for prolonged periods or “chronically”. 

Given the lack of studies on this regard, the intake of Melatonin should be avoided during pregnancy.


For people taking medication before starting with Pierpaoli’s Melatonin-Zinc-Selenium, as more generally, with any other type of dietary supplement, we recommend consulting with your doctor.

During a pharmacological therapy or in specific conditions, we recommend to take food supplements under the supervision of the doctor, who, knowing in depth his patient’s anamnesis, will be able to give the best advice.

Although the pharmacokinetic/pharmacodynamic characteristics of Melatonin are theoretically modulated by other active substances, at the moment there are no known interactions that are of particular concern from a clinical viewpoint.

Side effects

In clinical studies the most commonly observed adverse events during the intake of Melatonin, administrated at higher doses than those indicated, were drowsiness, nausea, headache and dizziness. However, the same side effects also occurred in subjects who were taking placebo and the occurrence of  side effects didn’t significantly differ from Melatonin compared to placebo. Indeed, in numerous clinical studies the percentage of patients who reported an adverse reaction was higher for placebo than for Melatonin, and therefore the Melatonin rate of undesirable events was lower than placebo.

Special population groups

For precautionary purposes, we recommend that you always consult your doctor before taking Melatonin if you suffer from: severe hepatic impairment and rheumatoid arthritis, given that, to date, there is not a great number of clinical observations in patients, it is necessary to validate the studies that prove the beneficial effects of Melatonin in these categories of people.

Given the lack of studies on this regard, taking Melatonin should be avoided during pregnancy and subsequently while breastfeeding.

In the absence of specific disorders healthy children and adolescents, with a lifestyle that does not affect the biological circadian rhythms (sleep-wake) usually do not suffer from inhibitions of the endogenous production of Melatonin and, therefore, unless a different specialised assessment proves otherwise, do not need to take Melatonin.

Prolonged use

The use of Melatonin has been demonstrated as being safe in the short and middle term (6-18 months), even at higher doses and more and more studies and clinical data prove the safety of long-term use.

However, for precautionary purposes, we advise you to inform your doctor if you use it for prolonged periods.


We produce supplements, pharmaceuticals and cosmetics, according to Dr. Walter Pierpaoli’s instructions.