Melatonina Zinco-Selenio Pierpaoli

Melatonin Zinc-Selenium


This formulation is the result of fundamental scientific observations, which surfaced and came to a head during the 40 years of research and clinical trials on Melatonin, the Pineal Gland and aging mechanisms conducted by Prof. Walter Pierpaoli and his collaborators.

Pierpaoli’s Melatonin Zinc-Selenium was developed with the intent of achieving a peak in the release of Melatonin during the night, which helps re-establish the nocturnal peak of melatonin.


Dietary supplement with melatonin, zinc and selenium.

Formula developed on the basis of clinical trials.


Melatonin contributes to reducing the time needed to fall asleep; the beneficial effect is obtained by taking 1 mg of Melatonin just before going to bed.


Melatonin contributes to reducing the effects of jet lag.


Zinc contributes to protecting cells from oxidative stress and the normal function of the immune system. Selenium contributes to protecting the cells from oxidative stress.


Average values per daily dose (1 tablet):
Melatonin 1 mg, Zinc 8,7 mg (NRV 87%), Selenium 50 mcg (NRV 90%)


Melatonin, Zinc gluconate, Seleniomethionine and Mannitol


Instruction for use

We recommend taking one tablet of Pierpaoli’s Melatonin Zinc-Selenium in the evening half an hour before going to sleep, and in any case preferably between 10 p.m. and midnight.


Do not exceed the recommended daily dose. Supplements are not intended as a substitute for a varied, balanced diet and healthy lifestyle. Keep out of reach of children under three years of age, do not take while pregnant, keep at a temperature below 25° C and protect from light. Excessive use may cause laxative effects.



Melatonin is a simple natural synthesized molecule, in addition to the pineal gland, it can also be found in numerous other organs and tissues such as, for example, the retina, intestinal mucosa, in megakaryocytes and in platelets. Melatonin is omnipresent in nature: it has also been found in many plants, including many for food use. In humans it is mainly synthesized by the pineal gland, which regulates the synthesis and cyclic secretion of hormones in our organism and is responsible for the nocturnal peak of melatonin. The nocturnal melatonin peak initiates a sequence of effects that keep the body in sync with the physiological cyclicity of hormones and cells. It is during childhood that the production of Melatonin reaches its peak, then begins to gradually decrease and dwindle away until it disappears in old age.


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Safety considerations for Pierpaoli’s Melatonin Zinc-Selenium


In general

The use of Melatonin at the recommended doses is safe. Melatonin is generally well tolerated and has no side effects. No harmful or dangerous side effects have been identified in the 20 years during which tens of millions of people have taken Melatonin. Numerous scientific publications and studies confirm the safety and beneficial effects of Melatonin. Melatonin is practically free of contraindications and clinically relevant undesirable effects when taken according to instructions.

Pierpaoli’s Melatonin Zinc-Selenium does not create addiction or dependency. Stopping the administration of exogenous Melatonin, the pineal gland resumes synthesizing the endogenous molecule in physiological quantities.


For people taking medication before starting with Pierpaoli’s Melatonin-Zinc-Selenium, as more generally, with any other type of dietary supplement, we recommend consulting with your doctor.

Although the pharmacokinetic/pharmacodynamic characteristics of Melatonin are theoretically modulated by other active substances, at the moment there are no known interactions that are of particular concern from a clinical viewpoint.

Special population groups

For precautionary purposes, we recommend that you always consult your doctor before taking Melatonin if you suffer from: severe hepatic impairment and rheumatoid arthritis, given that, to date, there is not a great number of clinical observations in patients, it is necessary to validate the studies that prove the beneficial effects of Melatonin in these categories of people.

Given the lack of studies in this regard, taking Melatonin should be avoided during pregnancy and subsequently while breastfeeding.

In the absence of specific disorders healthy children and adolescents, with a lifestyle that does not affect the biological circadian rhythms (sleep-wake) usually do not suffer from inhibitions of the endogenous production of Melatonin and, therefore, unless a different specialised assessment proves otherwise, do not need to take Melatonin.

Prolonged use

The use of Melatonin has been demonstrated as being safe in the short and middle term (6-18 months), even at higher doses.
However, for precautionary purposes, we advise you to inform your doctor if you use it for prolonged periods.


We produce supplements, pharmaceuticals and cosmetics, according to Dr. Walter Pierpaoli’s instructions.